Structure of PDB 7y82 Chain A Binding Site BS03

Receptor Information

>7y82 Chain A (length=1341) Species: 237368 (Candidatus Scalindua brodae)

MNITVELTFFEPYRLVEWFDWDARKKSHSAMRGQAFAQWTWKGKGRTAGK
SFITGTLVRSAVIKAVEELLSLNNGKWEGVPCCNGSFQTDESKGKKPSFL
RKRHTLQWQANNKNICDKEEACPFCILLGRFDNAGKVHERNKDYDIHFSN
FDLDHDLRLVDIASGRILNRVDFDTGKAKDYFRTWEADYETYGTYTGRIT
LRNEHAKKLLLASLGFVDKLCGALCRIEVIDHNDELRKQAEVIVEAFKQN
DKLEKIRILADAIRTLRLHGEGVIEKDELPDGKEERDKGHHLWDIKVQGT
ALRTKLKELWQSNKDIGWRKFTEMLGSNLYLIYKKETTEYYSSDLFIPVT
PPEGIETKEWIIVGRLKAATPFYFGVQQPSDSIPGKEVINEHTSFNILLD
KENRYRIPRSALRGALRRDLRTAFGSGCNVSLGGQILCNCKVCIEMRRIT
LKDSVSDFSEPPEIRYRIAKNPGTATVEDGSLFDIEVGPEGLTFPFVLRY
RGHKFPEQLSSVIRYWEENDGKNGMAWLGGLDSTGKGRFALKDIKIFEWD
LNQKINEYIKERGMRGKEKELLEMGESSLPDGLIPYKFFEERECLFPYKE
NLKPQWSEVQYTIEVGSPLLTADTISALTEPGNRDAIAYKKRVYNDGNNA
IEPEPRFAVKSETHRGIFRTAVGRRTGDLGKEDHEDCTCDMCIIFGNEHE
SSKIRFEDLELINGNEFEKLEKHIDHVAIDRFTGGALDKAKFDTYPLAGS
PKKPLKLKGRFWIKKGFSGDHKLLITTALSDIRDGLYPLGSKGGVGYGWV
AGISIDDNVINNDYVHPGHQSPKQDHKNKNIYYPHYFLDSGSKVYREKDI
ITHEEFTEELLSGKINCKLETLTPLIIPDTSDENGLKLQGNKPGHKNYKF
FNINGELMIPGSELRGMLRTHFEALTKSCFAIFGEDSTLSWRMNADEKDY
VRDKNRVFLNAANNNRQYLNNIKKSNHDLYLQYLKGEKKIRFGYPVDDQI
KKNYEDILDSYDGIKDQEVAERFDTFTRGSKLKVGDLVYFHIIDSLIPVR
ISRKCASKTLGGKLDKALHPCTGLSDGLCPGCHLFGTTDYKGRVKFGFAK
YENGPEWLITRGNNPERSLTLGVLESPRPAFSIPDDESEIPGRKFYLHHN
GWRIIRQKQLEIRETVQPERNVTTEVMDKGNVFSFDVRFENLREWELGLL
LQSLDPGKNIAHKLGKGKPYGFGSVKIKIDSLHTFKIKRVPQSDIREYIN
KGYQKLIEWSGLPQWHVIPHIDKLYKLLWVPFLNDSKLEPDVRYPVLNEE
SKGYIEGSDYTYKKLGDKDNLPYKTRVKGLTTPWSPWNPFQ

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7y82 Chain A Residue 1801

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7y82 Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase
• Resolution: 2.83 Å
• Binding residue (original residue number in PDB): H747 C750 C752 C755
• Binding residue (residue number reindexed from 1): H684 C687 C689 C692
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0051607 defense response to virus

External links

• PDB: RCSB:7y82, PDBe:7y82, PDBj:7y82
• PDBsum: 7y82
• PubMed: 36477448
• UniProt: A0A0B0EGF3