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Receptor Information

>7wx6 Chain A (length=267) Species: 446 (Legionella pneumophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PRGSMITQVNQLDELQLKDLKTLRAECKKNDGSIPNLYIHILKQHRSLPT
SFLYYQNGALIGFLSIYFFAVEVAVLVSPQYRRQGIAKQLIKEALPLLIF
SCPSRLNDNWLTSKGFTYLHSEYFMERDDLNPILIRPLSFRMATLEDIPI
LCGLDEVCFPDSVHRFQQILNEREYEIVIAMLNNHPIGKSHIRWQTKRAT
LSDIAILPKEQGKGFGSALIAHCINMILSEGKSRVDLDVETHNKKALNLY
IQLGFHIQNACDYWSIN

Ligand ID

CLM

InChI

InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1

InChIKey

WIIZWVCIJKGZOK-RKDXNWHRSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	c1cc(ccc1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]
CACTVS 3.341	OC[CH](NC(=O)C(Cl)Cl)[CH](O)c1ccc(cc1)[N+]([O-])=O
OpenEye OEToolkits 1.5.0	c1cc(ccc1[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]
CACTVS 3.341	OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
ACDLabs 10.04	ClC(Cl)C(=O)NC(C(O)c1ccc([N+]([O-])=O)cc1)CO

Formula

C11 H12 Cl2 N2 O5

Name

CHLORAMPHENICOL

PDB chain

7wx6 Chain A Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7wx6 Structural basis for the acetylation mechanism of the Legionella effector VipF.
Resolution	2.273 Å
Binding residue (original residue number in PDB)	N32 L33 Y34 E129 F131 E253 Y276
Binding residue (residue number reindexed from 1)	N36 L37 Y38 E122 F124 E240 Y263
Annotation score	3

Enzyme Commision number

	Molecular Function
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups

PDB	RCSB:7wx6, PDBe:7wx6, PDBj:7wx6
PDBsum	7wx6
PubMed	36048151
UniProt	Q5C8M4

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Structure of PDB 7wx6 Chain A Binding Site BS03