Structure of PDB 7wkv Chain A Binding Site BS03

Receptor Information

>7wkv Chain A (length=219) Species: 9606 (Homo sapiens)

QQLQKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYNEHT
VDRAPLRNKYFFGEGYTYGAQLQKRGPGQERLYPPGDVDEIPEWVHQLVI
QKLVEHRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSD
SALCFGCKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDI
KERRAVIILRKTRLDAPRL

Ligand information

• Ligand ID: AKG
• InChI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
• InChIKey: KPGXRSRHYNQIFN-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04: O=C(O)C(=O)CCC(=O)O
  OpenEye OEToolkits 1.7.6: C(CC(=O)O)C(=O)C(=O)O
  CACTVS 3.385: OC(=O)CCC(=O)C(O)=O
• Formula: C5 H6 O5
• Name: 2-OXOGLUTARIC ACID
• ChEMBL: CHEMBL1686
• DrugBank: DB08845
• ZINC: ZINC000001532519
• PDB chain: 7wkv Chain A Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7wkv Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): N193 Y195 H204 H266 I268 R277 V279 I281 R283
• Binding residue (residue number reindexed from 1): N120 Y122 H131 H193 I195 R204 V206 I208 R210
• Annotation score: 5

Enzymatic activity

• Enzyme Commision number: 1.14.11.53: mRNA N(6)-methyladenine demethylase.

Gene Ontology

Molecular Function

• GO:0035515 oxidative RNA demethylase activity

Biological Process

• GO:0006397 mRNA processing

External links

• PDB: RCSB:7wkv, PDBe:7wkv, PDBj:7wkv
• PDBsum: 7wkv
• PubMed: 35333330
• UniProt: Q6P6C2|ALKB5_HUMAN RNA demethylase ALKBH5 (Gene Name=ALKBH5)