Structure of PDB 7w02 Chain A Binding Site BS03

Receptor Information
>7w02 Chain A (length=1566) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSEN
VPNATIYPGQSIQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRRA
LVINMRVRGFPSEKDFEDYIRYDNCSSSVLAAVVFEHPFNHSKEPLPLAV
KYHLRFSYTRRNYEGWHTTSLFPLFPNPGPREPTSPDGGEPGYIREGFLA
VQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQL
PLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFF
LFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFM
VSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNV
AMAMGAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLY
GLVTWYMEAVFPGQFGVPQPWYFFIMPSYWNEYFEAEPEDLVAGIKIKHL
SKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPP
TSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKG
LSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKV
LILDQPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAI
MAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNAT
LESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEV
FLRVGKLVVKLNTGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTC
VTLALLAINYSSELFDDPMLRLTLGEYGRTVVPFSVPGTSQLGQQLSEHL
KDALQAEGQEPREVLGDLEEFLIFRASVEGGGFNERCLVAASFRDVGERT
VVNALFNNQAYHSPATALAVVDNLLFKLLCGPHASIVVSNFPQPRSALQA
AKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGV
HVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLL
LYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAV
KLEELSKTLDHVFLVLPNHCLGMAVSSFYENYETRRYCTSSEVAAHYCKK
YNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQRLLPED
QDVADERTRILALLHTPLIIKELSKVYEQRVPLLAVDRLSLAVQKGECFG
LLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDRIGYCPQFDALLD
HMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGN
KRKLSTGIALIGEPAVIFLDQPSTGMDPVARRLLWDTVARARESGKAIII
TSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQEAL
EEFKAFVDLTFPGSVLEDEHQGMVHYHLPWAKVFGILEKAKEKYGVDDYS
VSQISLEQVFLSFAHL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7w02 Chain A Residue 1803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7w02 Cryo-EM structures of the human surfactant lipid transporter ABCA3.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		T573 Q613
Binding residue
(residue number reindexed from 1)		T538 Q578
Annotation score1
Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
7.6.2.2: ABC-type xenobiotic transporter.
Gene Ontology
Molecular Function
GO:0005319 lipid transporter activity
GO:0005524 ATP binding
GO:0008559 ABC-type xenobiotic transporter activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0120019 phosphatidylcholine transfer activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140345 phosphatidylcholine flippase activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006855 xenobiotic transmembrane transport
GO:0006869 lipid transport
GO:0009410 response to xenobiotic stimulus
GO:0010875 positive regulation of cholesterol efflux
GO:0015914 phospholipid transport
GO:0030324 lung development
GO:0032368 regulation of lipid transport
GO:0032464 positive regulation of protein homooligomerization
GO:0034204 lipid translocation
GO:0042908 xenobiotic transport
GO:0043129 surfactant homeostasis
GO:0046470 phosphatidylcholine metabolic process
GO:0046471 phosphatidylglycerol metabolic process
GO:0046618 xenobiotic export from cell
GO:0046890 regulation of lipid biosynthetic process
GO:0051384 response to glucocorticoid
GO:0055085 transmembrane transport
GO:0055091 phospholipid homeostasis
GO:0070925 organelle assembly
GO:0120009 intermembrane lipid transfer
GO:0150172 regulation of phosphatidylcholine metabolic process
GO:1902995 positive regulation of phospholipid efflux
GO:2001140 positive regulation of phospholipid transport
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0032585 multivesicular body membrane
GO:0042599 lamellar body
GO:0043231 intracellular membrane-bounded organelle
GO:0097208 alveolar lamellar body
GO:0097232 lamellar body membrane
GO:0097233 alveolar lamellar body membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7w02, PDBe:7w02, PDBj:7w02
PDBsum7w02
PubMed35394827
UniProtQ99758|ABCA3_HUMAN Phospholipid-transporting ATPase ABCA3 (Gene Name=ABCA3)

[Back to BioLiP]