Structure of PDB 7vdt Chain A Binding Site BS03

Receptor Information

>7vdt Chain A (length=617) Species: 9606 (Homo sapiens)

KLIDQKKDKRLAYLLQQTDEYYAVAHAVTERVDKQSALMVNGVLKQYQIK
GLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIV
PLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTY
EYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLT
GTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEE
TILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRH
MQAKGVLLTDGSGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGG
IVQGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAY
RGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSA
DTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAA
KYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDET
VNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKEK
MFGRGSRHRKEVDYSDS

Ligand information

• Ligand ID: BEF
• InChI: InChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3
• InChIKey: OGIAHMCCNXDTIE-UHFFFAOYSA-K
• SMILES:
  OpenEye OEToolkits 1.5.0: [Be-](F)(F)F
  ACDLabs 10.04
  CACTVS 3.341: F[Be-](F)F
• Formula: Be F3
• Name: BERYLLIUM TRIFLUORIDE ION
• PDB chain: 7vdt Chain A Residue 1701

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7vdt Structure of human chromatin-remodelling PBAF complex bound to a nucleosome.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): M781 R1189 R1192
• Binding residue (residue number reindexed from 1): M71 R471 R474
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0042393 histone binding
• GO:0140658 ATP-dependent chromatin remodeler activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:7vdt, PDBe:7vdt, PDBj:7vdt
• PDBsum: 7vdt
• PubMed: 35477757
• UniProt: P51532|SMCA4_HUMAN Transcription activator BRG1 (Gene Name=SMARCA4)