Structure of PDB 7v5c Chain A Binding Site BS03

Receptor Information
>7v5c Chain A (length=572) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDSIVIQKS
MDQFTTAVVVVCLLAIGSSLAAGIRGGIFTLVFARLNIRLRNCLFRSLVS
QETSFFDENRTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFM
FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQSALARASTTAEET
ISAMKTVRSFANEEEEAEVFLRKLQQVYKLNRKEAAAYMSYVWGSGLTLL
VVQVSILYYGGHLVISGQMSSGNLIAFIIYEFVLGDCMESVGSVYSGLMQ
GVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQV
LQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLQGGRVLLDGKPIG
AYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANA
HGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATS
ALDAESEYLIQQAIHGNLQRHTVLIIAHRLSTVERAHLIVVLDKGRVVQQ
GTHQQLLAQGGLYAKLVQRQML
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7v5c Chain A Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7v5c The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		S542 Q583
Binding residue
(residue number reindexed from 1)		S375 Q416
Annotation score1
Enzymatic activity
Enzyme Commision number 7.4.2.6: ABC-type oligopeptide transporter.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0015421 ABC-type oligopeptide transporter activity
GO:0015440 ABC-type peptide transporter activity
GO:0016887 ATP hydrolysis activity
GO:0022857 transmembrane transporter activity
GO:0042803 protein homodimerization activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006518 peptide metabolic process
GO:0015031 protein transport
GO:0015833 peptide transport
GO:0035672 oligopeptide transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7v5c, PDBe:7v5c, PDBj:7v5c
PDBsum7v5c
PubMed36195619
UniProtQ9JJ59|ABCB9_MOUSE ABC-type oligopeptide transporter ABCB9 (Gene Name=Abcb9)

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