Structure of PDB 7uih Chain A Binding Site BS03

Receptor Information

>7uih Chain A (length=574) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RFPEALRLALMLNDMELVEDIFTSCKDVVVQKQMAFMLGRHGVFLELSED
VEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYSARMNLASSFV
NGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLT
QIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDFVLHNSNTM
RLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAV
GSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAIL
AALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSK
FSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMV
RLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILG
KSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQQTHTTPVLLAHGER
AELATEEFLPVTPILEGFVILRKN

Ligand information

>7uih Chain E (length=18) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

SVSSAVYSASSYYYSSSL

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7uih Targeted degradation via direct 26S proteasome recruitment.
Resolution	3.1 Å
Binding residue (original residue number in PDB)	A464 L465
Binding residue (residue number reindexed from 1)	A187 L188

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:7uih, PDBe:7uih, PDBj:7uih
PDBsum	7uih
PubMed	36577875
UniProt	Q13200\|PSMD2_HUMAN 26S proteasome non-ATPase regulatory subunit 2 (Gene Name=PSMD2)

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