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Receptor Information

>7tuv Chain A (length=672) Species: 5691 (Trypanosoma brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ALFSPHLAESALDLGVQNGTYLRGKLRVSETNCFFGEIRGQWKGHNFERV
LLPGRTNLNRAIHGDIVTVELLPVASWRPLREESEGAALARGYTPVGRVV
GITTMNRRPFCGSIDVEELNKLALTGTVSVLFQPKDNRIPRIRITTAHLG
DLKDKRLSVIIDDWGEHSSFPVGHYVEVLGTIGDKDTEAKVILLENDIPH
YDFSEAVYDCLPKGEWNVTEEELGNRLDLRDLCVVSVDPLGCRDIDDALH
CRRVNGNHLEVGVHIADVTHFLKEGTAMDEEAAKRSTSVYLVDRRINMLP
QLLTENLCSIVADEDRYAFSIMWEFDENYSVVREFFGKTVIRSRAALYYG
DAQRMIDDPEDESEAAVSLRYLMQLSRHFRKRREKDGALFLCSQEFKFKV
DNDHVNPTDMQAYQTFDSNSMIEEWMLFANAAAARRVYASFPRWTLLRRH
QAPAENAFDTLNEAIRRKIGVKLDDTTSLALNESLEKCVDPSDPYFNRLI
RTLVTRCLRQAQYFSSSEVSKDEFHHFGLAMPIYTHFTSPIRRYADVIVH
RQLAAALGIMDVSEHMVSVKMEALASNLNYRHEQAQKAGRDSQNLFTGFY
LRNFANQEIPSEDGYVVKLSETHVFVLVPKYGQEGKIAKETLVRVPNLLD
KVKVGIEVRASLVFSIIGLMKG

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

7tuv Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7tuv Trypanosoma brucei RRP44: a versatile enzyme for processing structured and non-structured RNA substrates.
Resolution	2.225 Å
Binding residue (original residue number in PDB)	D503 D511 D512
Binding residue (residue number reindexed from 1)	D238 D246 D247
Annotation score	4

Enzyme Commision number

	Molecular Function
GO:0003723	RNA binding
GO:0004540	RNA nuclease activity

PDB	RCSB:7tuv, PDBe:7tuv, PDBj:7tuv
PDBsum	7tuv
PubMed	36583334
UniProt	Q95Z12

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Structure of PDB 7tuv Chain A Binding Site BS03