Structure of PDB 7t3i Chain A Binding Site BS03

Receptor Information
>7t3i Chain A (length=577) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLL
HGPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEA
IRLAPCLIFLDEIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGK
NVVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLA
DDINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPAD
HLANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREG
FSTIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLW
GPPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAK
SSAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVI
GATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTD
ADLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEIEP
VITMEDWEKALNEVKPSVKDPEKYMHS
Ligand information
Ligand IDATP
InChIInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
FormulaC10 H16 N5 O13 P3
NameADENOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL14249
DrugBankDB00171
ZINCZINC000004261765
PDB chain7t3i Chain A Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7t3i Communication network within the essential AAA-ATPase Rix7 drives ribosome assembly.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		I204 A205 G246 C247 G248 K249 T250 T251 I380 G408 S409
Binding residue
(residue number reindexed from 1)		I13 A14 G55 C56 G57 K58 T59 T60 I189 G217 S218
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:1990275 preribosome binding
Biological Process
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t3i, PDBe:7t3i, PDBj:7t3i
PDBsum7t3i
PubMed36090660
UniProtG0RZG1

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