Structure of PDB 7sxo Chain A Binding Site BS03

Receptor Information
>7sxo Chain A (length=544) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYKERIKSLKLPDSVQKIFDDEITKLSTLETSMSEFGVIRNYLDWLTSIP
WGKHSKEQYSIPRAKKILDEDHYGMVDVKDRILEFIAVGKLLGKVDGKII
CFVGPPGVGKTSIGKSIARALNRKFFRFSVGGMTDVAEIKGHRRTYIGAL
PGRVVQALKKCQTQNPLILIDEIDKIGHGGIHGDPSAALLEVLDPEQNNS
FLDNYLDIPIDLSKVLFVCTANSLETIPRPLLDRMEVIELTGYVAEDKVK
IAEQYLVPSAKKSAGLENSHVDMTEDAITALMKYYCRESGVRNLKKHIEK
IYRKAALQVVKKLSKINVSISQKNLKDYVGPPVYTTDRLYETTPPGVVMG
LAWTNMGGCSLYVESVLEQPLHHPTFERTGQLGDVMKESSRLAYSFAKMY
LAQKFPENRFFEKASIHLHCPEGATPKDGPSAGVTMATSFLSLALNSIDP
TVAMTGELTLTGKVLRIGGLREKAVAAKRSGAKTIIFPKDNLNDWEELPD
NVKEGLEPLAADWYNDIFQKLFKDVNTKEGNSVWKAEFEILDAK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7sxo Chain A Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7sxo Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		S657 G659
Binding residue
(residue number reindexed from 1)		S129 G131
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.21.53: endopeptidase La.
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006508 proteolysis
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0030163 protein catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7sxo, PDBe:7sxo, PDBj:7sxo
PDBsum7sxo
PubMed35143841
UniProtP36775|LONM_YEAST Lon protease homolog, mitochondrial (Gene Name=PIM1)

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