Structure of PDB 7sum Chain A Binding Site BS03

Receptor Information
>7sum Chain A (length=645) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVET
LSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKAVAQA
TGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDI
ARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLA
ALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVP
DLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEA
AFTCEYKYDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIKLP
SVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFD
LIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFL
EQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVV
IGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQS
LKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGL
VDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQ
Ligand information
Receptor-Ligand Complex Structure
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PDB7sum Structures of LIG1 that engage with mutagenic mismatches inserted by pol beta in base excision repair.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R305 T415 G416 A418 T420 R451 G453 A455 Q457 S458 T639 T640 K642 R643 R738 K770 G776 K795 S850 S852 P853 Y855 S869 L870
Binding residue
(residue number reindexed from 1)		R44 T154 G155 A157 T159 R190 G192 A194 Q196 S197 T378 T379 K381 R382 R477 K509 G515 K534 S589 S591 P592 Y594 S608 L609
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7sum, PDBe:7sum, PDBj:7sum
PDBsum7sum
PubMed35790757
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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