Structure of PDB 7sl4 Chain A Binding Site BS03

Receptor Information
>7sl4 Chain A (length=786) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFP
KLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLK
ELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDNC
PATFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTK
CVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRCHQY
VIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQIGEKTIDSVTSAQE
LRGCTVINGSLIINIRGAAELEANLGLIEEISGFLKIRRSYALVSLSFFR
KLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPK
LCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFD
KILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFSNSWTVVDIDPPQRS
HPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSV
PLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYC
LKGLKLPSRQILKELEESSFRKTFEDYLHNVVFVPRHRPFEKVVNKESLV
ISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKADDIVGPVT
HEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALE
RGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYV
Ligand information
>7sl4 Chain E (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIVEQCCTSICSLYQLENYCN
Receptor-Ligand Complex Structure
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PDB7sl4 Synergistic activation of the insulin receptor via two distinct sites.
Resolution5.0 Å
Binding residue
(original residue number in PDB)		D496 H712 N713 F716 V717 P718 R719
Binding residue
(residue number reindexed from 1)		D463 H629 N630 F633 V634 P635 R636
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sl4, PDBe:7sl4, PDBj:7sl4
PDBsum7sl4
PubMed35361965
UniProtP15208|INSR_MOUSE Insulin receptor (Gene Name=Insr)

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