Structure of PDB 7r2v Chain A Binding Site BS03

Receptor Information
>7r2v Chain A (length=440) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
THLSVDTKFKTEGLCIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEA
IRHVRAWIGFAVANLPLQLGFSTGVNLVAVPTKGLPWNVVRIKIVQMLSD
TLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASD
TYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASC
DAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALL
ADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYAT
HSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVN
KHAFHTPAFDKSAFVNLKQLPFFYYSDSPCEVPLKSATCITRCNLGGAVC
RHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7r2v Chain A Residue 605 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7r2v Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.
Resolution2.53 Å
Binding residue
(original residue number in PDB)		C207 C210 C226 H229
Binding residue
(residue number reindexed from 1)		C135 C138 C154 H157
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004532 RNA exonuclease activity
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7r2v, PDBe:7r2v, PDBj:7r2v
PDBsum7r2v
PubMed35609600
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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