Structure of PDB 7r2t Chain A Binding Site BS03

Receptor Information
>7r2t Chain A (length=416) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALD
GRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQGSA
YGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAF
AYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGT
DEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVA
LAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVP
HLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADR
LYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDT
KGDYQKALLYLCGGDD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7r2t Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7r2t SYNJ2BP PDZ domain in complex with a synthetic Vangl2 peptide.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		G285 R288 K289 G290 E330
Binding residue
(residue number reindexed from 1)		G279 R282 K283 G284 E324
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008092 cytoskeletal protein binding

View graph for
Molecular Function
External links
PDB RCSB:7r2t, PDBe:7r2t, PDBj:7r2t
PDBsum7r2t
PubMed38142947
UniProtP57105|SYJ2B_HUMAN Synaptojanin-2-binding protein (Gene Name=SYNJ2BP)

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