Structure of PDB 7qnz Chain A Binding Site BS03

Receptor Information
>7qnz Chain A (length=640) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVET
LSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQA
TGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDI
ARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLA
ALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVP
DLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEA
AFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLP
SVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFD
LIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFL
EQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVV
IGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQS
LKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGL
VDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQS
Ligand information
Receptor-Ligand Complex Structure
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PDB7qnz Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.
Resolution4.58 Å
Binding residue
(original residue number in PDB)		A418 S419 R449 R451 G453 L454 A455 S458 H546 R557 Q636 T639 R641 K642 R643 R738 K770 G776 C794 K795 G797 S850 S852 P853 Y855 S869 L870
Binding residue
(residue number reindexed from 1)		A157 S158 R188 R190 G192 L193 A194 S197 H285 R296 Q375 T378 R380 K381 R382 R477 K509 G515 C533 K534 G536 S589 S591 P592 Y594 S608 L609
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006266 DNA ligation
GO:0006273 lagging strand elongation
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006298 mismatch repair
GO:0006310 DNA recombination
GO:0009653 anatomical structure morphogenesis
GO:0033151 V(D)J recombination
GO:0051301 cell division
GO:0071897 DNA biosynthetic process
GO:1903461 Okazaki fragment processing involved in mitotic DNA replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qnz, PDBe:7qnz, PDBj:7qnz
PDBsum7qnz
PubMed36539424
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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