Structure of PDB 7q0w Chain A Binding Site BS03

Receptor Information

>7q0w Chain A (length=223) Species: 9913 (Bos taurus)

IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRL
GEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRV
ASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKS
AYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQK
NKPGVYTKVCNYVSWIKQTIASN

Ligand information

• Ligand ID: O
• InChI: InChI=1S/H2O/h1H2
• InChIKey: XLYOFNOQVPJJNP-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: O
  CACTVS 3.341: [O]
• Formula: O
• Name: OXYGEN ATOM
• ChEMBL: CHEMBL1098659
• DrugBank: DB09145
• PDB chain: 7q0w Chain A Residue 308

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7q0w Binding of V IV O 2+ , V IV OL, V IV OL 2 and V V O 2 L Moieties to Proteins: X-ray/Theoretical Characterization and Biological Implications.
• Resolution: 1.2 Å
• Binding residue (original residue number in PDB): Q192 G193 S195
• Binding residue (residue number reindexed from 1): Q174 G175 S177
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.21.4: trypsin.

Gene Ontology

Molecular Function

• GO:0004175 endopeptidase activity
• GO:0004252 serine-type endopeptidase activity
• GO:0005515 protein binding
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding
• GO:0097655 serpin family protein binding

Biological Process

• GO:0006508 proteolysis
• GO:0007586 digestion

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0097180 serine protease inhibitor complex

External links

• PDB: RCSB:7q0w, PDBe:7q0w, PDBj:7q0w
• PDBsum: 7q0w
• PubMed: 35486702
• UniProt: P00760|TRY1_BOVIN Serine protease 1 (Gene Name=PRSS1)