Structure of PDB 7prw Chain A Binding Site BS03

Receptor Information
>7prw Chain A (length=326) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCI
IDKIRRKNCPACRYRKCLQAGMNLPQLTPTLVSLLEVIEPEVLYAGYDSS
VPDSTWRIMTTLNMLGGRQMIAAVKWAKAIPGFRNLHLDDQMTLLQYSWM
SLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPDMYDQCKHMLYVSS
ELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAI
VKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPE
MLAEIITNQIPKYSNGNIKKLLFHQK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7prw Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.
Resolution2.502 Å
Binding residue
(original residue number in PDB)		K579 R585 M593 E751 M752 E755
Binding residue
(residue number reindexed from 1)		K128 R134 M142 E300 M301 E304
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7prw, PDBe:7prw, PDBj:7prw
PDBsum7prw
PubMed36747092
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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