Structure of PDB 7pks Chain A Binding Site BS03

Receptor Information
>7pks Chain A (length=1392) Species: 9825 (Sus scrofa domesticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICGGCGRY
QPRIRRSGLELYAEWKKKILLSPERVHEIFKRISDEECFVLGMEPRYARP
EWMIVTVLPVPPLSVRPAVRNQDDLTHKLADIVKINNQLRRNEQNGAAAH
VIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVR
GNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDR
LQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHMC
DGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDEM
NLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKR
DVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHIN
CIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGS
LVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQD
IQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDK
TGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFG
FKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTA
VKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESV
EFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNE
LEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLP
SDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLCS
RRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQ
MVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTT
LRKVTANTAIYYDPNPQSTVVAEDQEWVNVISPWLLRVELDRKHMTDRKL
TMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNDDDVFLRCIESNM
LTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVS
LMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALERELYHVISFDGSY
VNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLMEA
AAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pks Structural basis of Integrator-mediated transcription regulation.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		P323 K331 S332 K346 Y859 R1416 E1434
Binding residue
(residue number reindexed from 1)		P272 K280 S281 K295 Y808 R1324 E1342
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pks, PDBe:7pks, PDBj:7pks
PDBsum7pks
PubMed34762484
UniProtA0A7M4DUC2

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