Structure of PDB 7pim Chain A Binding Site BS03

Receptor Information

>7pim Chain A (length=335) Species: 9606 (Homo sapiens)

VPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQ
YRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFS
GYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQ
YIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEE
IEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAF
DPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPY
TLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG

Ligand information

• Ligand ID: FE
• InChI: InChI=1S/Fe/q+3
• InChIKey: VTLYFUHAOXGGBS-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Fe+3]
• Formula: Fe
• Name: FE (III) ION
• DrugBank: DB13949
• PDB chain: 7pim Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7pim Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation.
• Resolution: 4.6 Å
• Binding residue (original residue number in PDB): H330 H335 E375
• Binding residue (residue number reindexed from 1): H168 H173 E213
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.14.16.2: tyrosine 3-monooxygenase.

Gene Ontology

Molecular Function

• GO:0004497 monooxygenase activity
• GO:0005506 iron ion binding
• GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

Biological Process

• GO:0009072 aromatic amino acid metabolic process

External links

• PDB: RCSB:7pim, PDBe:7pim, PDBj:7pim
• PDBsum: 7pim
• PubMed: 35013193
• UniProt: P07101|TY3H_HUMAN Tyrosine 3-monooxygenase (Gene Name=TH)