Structure of PDB 7pag Chain A Binding Site BS03

Receptor Information
>7pag Chain A (length=509) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PCYTATRSECKQKHKFVPGVWMAGEGMDVTTLRRSGSFPVNTQRFLRPDR
TCTLCKNSLMRDATQRLPVAITHWRPHSSHCQRNVAAAKVHSTEGVAREA
AANINNDWRVGLDVNPRPEANMRASVAGSHSKVANFAAEKTYQDQYNFNS
DTVECRMYSFRLVQKPPLHLDFKKALRALPRNFNSSTEHAYHRLISSYGT
HFITAVDLGGRISVLTALRTCQLTLNGLTADEVGDCLNVEAQVSIGAQAS
VSSEYKACEEKKKQHKMATSFHQTYRERHVEVLGGPLDSTHDLLFGNQAT
PEQFSTWTASLPSNPGLVDYSLEPLHTLLEEQNPKREALRQAISHYIMSR
ARWQNCSRPCCQCECQDSKVTNQDCCPRQRGLAHLVVSNFRAEHLWGDYT
TATDAYLKVFFGGQEFRTGVVWNNNNPRWTDKMDFENVLLSTGGPLRVQV
WDADYGWDDDLLGSCDRSPHSGFHEVTCELNHGRVKFSYHAKCLPHLTGG
TCLEYAPQG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7pag Chain A Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7pag The pore conformation of lymphocyte perforin.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		G428 Y430 D483 D485 D491
Binding residue
(residue number reindexed from 1)		G397 Y399 D452 D454 D460
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0022829 wide pore channel activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0140911 pore-forming activity
Biological Process
GO:0001771 immunological synapse formation
GO:0001909 leukocyte mediated cytotoxicity
GO:0001913 T cell mediated cytotoxicity
GO:0002357 defense response to tumor cell
GO:0002418 immune response to tumor cell
GO:0009306 protein secretion
GO:0017038 protein import
GO:0031640 killing of cells of another organism
GO:0051260 protein homooligomerization
GO:0051607 defense response to virus
GO:0051712 positive regulation of killing of cells of another organism
GO:0071806 protein transmembrane transport
GO:0140507 granzyme-mediated programmed cell death signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005576 extracellular region
GO:0005764 lysosome
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0031904 endosome lumen
GO:0044194 cytolytic granule

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pag, PDBe:7pag, PDBj:7pag
PDBsum7pag
PubMed35148176
UniProtP10820|PERF_MOUSE Perforin-1 (Gene Name=Prf1)

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