Structure of PDB 7orw Chain A Binding Site BS03

Receptor Information
>7orw Chain A (length=124) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TMGNSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAIT
VTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCAND
PVGFTLKNTVCTVCGMWKGYGCSC
Ligand information
Ligand ID7WA
InChIInChI=1S/C7H7N3/c8-5-2-1-3-6-7(5)10-4-9-6/h1-4H,8H2,(H,9,10)
InChIKeyNZJKEQFPRPAEPO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385Nc1cccc2[nH]cnc12
ACDLabs 12.01c21c(cccc1N)ncn2
OpenEye OEToolkits 2.0.6c1cc(c2c(c1)[nH]cn2)N
FormulaC7 H7 N3
Name1H-benzimidazol-4-amine
ChEMBL
DrugBank
ZINCZINC000000112552
PDB chain7orw Chain A Residue 203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7orw Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		H48 M63 E66
Binding residue
(residue number reindexed from 1)		H42 M57 E60
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008270 zinc ion binding
Biological Process
GO:0019079 viral genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7orw, PDBe:7orw, PDBj:7orw
PDBsum7orw
PubMed35128408
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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