Structure of PDB 7orr Chain A Binding Site BS03

Receptor Information
>7orr Chain A (length=124) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TMGNSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAIT
VTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCAND
PVGFTLKNTVCTVCGMWKGYGCSC
Ligand information
Ligand IDPIM
InChIInChI=1S/C9H8N2/c1-2-4-8(5-3-1)9-6-10-7-11-9/h1-7H,(H,10,11)
InChIKeyXHLKOHSAWQPOFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1ccc(cc1)c2cnc[nH]2
ACDLabs 10.04n2cc(c1ccccc1)nc2
CACTVS 3.341[nH]1cncc1c2ccccc2
FormulaC9 H8 N2
Name4-PHENYL-1H-IMIDAZOLE
ChEMBLCHEMBL14145
DrugBankDB03254
ZINCZINC000004692811
PDB chain7orr Chain A Residue 205 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7orr Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16.
Resolution1.79 Å
Binding residue
(original residue number in PDB)		T12 S15
Binding residue
(residue number reindexed from 1)		T6 S9
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008270 zinc ion binding
Biological Process
GO:0019079 viral genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7orr, PDBe:7orr, PDBj:7orr
PDBsum7orr
PubMed35128408
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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