Structure of PDB 7oro Chain A Binding Site BS03

Receptor Information
>7oro Chain A (length=2008) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDYQEYQQFLARINTARDACVAKDIDVDLLMARKDYFGRELCKSLNIEYR
NDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSNE
SSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELYP
TIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVAHGDFTLTAPWCKTGCPE
FWKHPIYKEFKMSMPVPERRLFEESVKFNAYESERWNTNLVKIREYTKKD
YSEHISKSAKNIFLASGFYKQPNKNEISEGWTLMVERVQDQREISKSLHD
QKPSIHFIWGAHNPGNSNNATFKLILLSKSLQSIKGISTYTEAFKSLGKM
MDIGDKAIEYEEFCMSLKSKARSSWKQIMNKKLEPKQINNALVLWEQQFM
INNDLIDKSEKLKLFKNFCGIGKHVSKPKILDFDDANMYLASLTMMEQSK
KILSKSNGLKPDNFILNEFGSRIKDANKETYDNMHKIFETGYWQCISDFS
TLMKNILSVSQYNRHNTFRIAMCANNNVFAIVFPSAKATVVYSIIVLHKE
EENIFNPGCLHGTFKCMNGYISISRAIRLDKERCQRIVSSPGLFLTTCLL
FKHDNPTLVMSDIMNFSIYTSLSITKSVLSLTEPARYMIMNSLAISSNVK
DYIAEKFSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDIYLSDYDIT
QKGIKDNRELTSIWFPGSVTLKEYLTQIYLPFYFNAKGLHEKHHVMVDLA
KTILEIECEQRENIKEIWSTNCTKQTVNLKILIHSLCKNLLADTSRHNHL
RNRIENRNNFRRSITTISTFTSSKSCLKIGDFRKEKEYEMLRNAMPNYTD
YISTKVFDRLYELLDKKVLTDKPVIEQIMDMMIDHKKFYFTFFNKGQKTS
KDREIFVGEYEAKMCMYAVERIAKERCKLNPDEMISEPGDGKLKVLEQKS
EQEIRFLVETTRQKNREIDEAIEIEKLSLGKAKGLKMEINADMSKWSAQD
VFYKYFWLIALDPILYPQEKERILYFMCNYMDKELILPDELLFNLLDQKV
AYQNDIIATMTNQLNSNTVLIKRNWLQGNFNYTSSYVHSCAMSVYKEILK
EAITLLDGSILVNSLVHSDDNQTSITIVQDKMENDKIIDFAMKEFERACL
TFGCQANMKKTYVTNCIKEFVSLFNLYGEPFSIYGRFLLTSVGDCAYIGP
YEDLASRISSAQTAIKHGCPPSLAWVSIAISHWMTSLTYNMLPGQSNDPI
DYFPAENRKDIPIELNGVLDAPLSMISTVGLESGNLYFLIKLLSKYTPVM
QKRESVVNQIAEVKNWKVEDLTDNEIFRLKILRYLVLDAEMDPSDIMGET
SDMRGRSILTPRKFTTAGSLRKLYSFSKYQDRLSSPGGMVELFTYLLEKP
ELLVTKGEDMKDYMESVIFRYNSKRFKESLSIQNPAQLFIEQILFSHKPV
IDFSGIRDKYINLGKVTFTEAYRLLMRDLSSLELTNDDIQVIYSYIILND
PMMITIANTHILSIYGSPQRRMGMSCSTMPEFRNLKLIHHSPALVLRAYS
KNNPDIQGADPTEMARDLVHLKEFVENTNLEEKMKVRIAMNEAEKGQRDI
VFELKEMTRFYQVCYEYVKSTEHKIKVFILPAKSYTTTDFCSLMQGNLIK
DKEWYTVHYLKQILSGGHKAIMQHNATSEQNIAFECFKLITHFADSFIDS
LSRSAFLQLIIDEFSYKDVKVSKLYDIIKNGYNRTDFIPLLFRTGDLRQA
DLDKYDAMKILIRSLDYLNNDIFSLSRIKVGLDEFATIKKAHFSKMVSFE
GPPIKTGLLDLTELMKSQDLLNLNYDNIRNSNLISFSKLICCEGSDNIND
GLEFLSDDPMNFTEGEAIHSTPIFNIYYSKRGERHMTYRNAIKLLIERET
KIFEEAFTFSENGFISPENLGCLEAVVSLIKLLKTNEWSTVIDKCIHICL
IKNGMDHMYHSFDVPKCFINWVMFREFINSLPGTDIPPWNVMTENFKKKC
IALINSKF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7oro Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		K841 S842 S908 F948 I960 F961 V962 R976 K979 P993 G994 G1146 Y1150 Y1269 A1273 S1425 K1705 I1706
Binding residue
(residue number reindexed from 1)		K824 S825 S853 F893 I905 F906 V907 R921 K924 P938 G939 G1078 Y1082 Y1201 A1205 S1357 K1624 I1625
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7oro, PDBe:7oro, PDBj:7oro
PDBsum7oro
PubMed35173159
UniProtA5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)

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