Structure of PDB 7orm Chain A Binding Site BS03

Receptor Information
>7orm Chain A (length=2145) Species: 11577 (La Crosse virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDYQEYQQFLARINTARDACVAKDIDVDLLMARKDYFGRELCKSLNIEYR
NDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSNE
SSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELYP
TIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVAHGDFTLTAPWCKTGCPE
FWKHPIYKEFKMSMPVPERRLFEESVKFNAYESERWNTNLVKIREYTKKD
YSEHISKSAKNIFLASGFYKQPNKNEISEGWTLMVERVQDQREISKSLHD
QKPSIHFIWGAHNPGNSNNATFKLILLSKSLQSIKGISTYTEAFKSLGKM
MDIGDKAIEYEEFCMSLKSKARSSWKQIMNKKLEPKQINNALVLWEQQFM
INNDLIDKSEKLKLFKNFCGIGKHKQEVSKPKILDFDDANMYLASLTMME
QSKKILSKSNGLKPDNFILNEFGSRIKDANKETYDNMHKIFETGYWQCIS
DFSTLMKNILSVSQYNRHNTFRIAMCANNNVFAIVFPSADIKTKKATVVY
SIIVLHKEEENIFNPGCLHGTFKCMNGYISISRAIRLDKERCQRIVSSPG
LFLTTCLLFKHDNPTLVMSDIMNFSIYTSLSITKSVLSLTEPARYMIMNS
LAISSNVKDYIAEKFSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDI
YLSDYDITQKGIKDNRELTSIWFPGSVTLKEYLTQIYLPFYFNAKGLHEK
HHVMVDLAKTILEIECEQRENIKEIWSTNCTKQTVNLKILIHSLCKNLLA
DTSRHNHLRNRIENRNNFRRSITTISTFTSSKSCLKIGDFRKEKENYEML
RNAMPNYTDYISTKVFDRLYELLDKKVLTDKPVIEQIMDMMIDHKKFYFT
FFNKGQKTSKDREIFVGEYEAKMCMYAVERIAKERCKLNPDEMISEPGDG
KLKVLEQKSEQEIRFLVETTRQKNREIDEAIEIEKLSLGKAKGLKMEINA
DMSKWSAQDVFYKYFWLIALDPILYPQEKERILYFMCNYMDKELILPDEL
LFNLLDQKVAYQNDIIATMTNQLNSNTVLIKRNWLQGNFNYTSSYVHSCA
MSVYKEILKEAITLLDGSILVNSLVHSDDNQTSITIVQDKMENDKIIDFA
MKEFERACLTFGCQANMKKTYVTNCIKEFVSLFNLYGEPFSIYGRFLLTS
VGDCAYIGPYEDLASRISSAQTAIKHGCPPSLAWVSIAISHWMTSLTYNM
LPGQSNDPIDYFPAENRKDIPIELNGVLDAPLSMISTVGLESGNLYFLIK
LLSKYTPVMQKRESVVNQIAEVKNWKVEDLTDNEIFRLKILRYLVLDAEM
DPSDIMGETSDMRGRSILTPRKFTTAGSLRKLYSFSKYQDRLSSPGGMVE
LFTYLLEKPELLVTKGEDMKDYMESVIFRYNSKRFKESLSIQNPAQLFIE
QILFSHKPVIDFSGIRDKYINLGKVTFTEAYRLLMRDLSSLELTNDDIQV
IYSYIILNDPMMITIANTHILSIYGSPQRRMGMSCSTMPEFRNLKLIHHS
PALVLRAYSKNNPDIQGADPTEMARDLVHLKEFVENTNLEEKMKVRIAMN
EAEKGQRDIVFELKEMTRFYQVCYEYVKSTEHKIKVFILPAKSYTTTDFC
SLMQGNLIKDKEWYTVHYLKQILSGGHKAIMQHNATSEQNIAFECFKLIT
HFADSFIDSLSRSAFLQLIIDEFSYKDVKVSKLYDIIKNGYNRTDFIPLL
FRTGDLRQADLDKYDAMKSHERVTLTITGYNRSITIIGEDNKLTYAELCL
TRKTPENITISGRKLLGSRHGLKFENMSKIQNYYITYRKKDRHQFVYQIH
SHESITRRNEEHNEITPVCVVNVAEVDGDQRILIRSLDYLNNDIFSLSRI
KVGLDEFATIKKAHFSKMVSFEGPPIKTGLLDLTELMKSQDLLNLNYDNI
RNSNLISFSKLICCEGSDNINDGLEFLSDDPMNFTEGEAIHSTPIFNIYY
SKRGERHMTYRNAIKLLIERETKIFEEAFTFSENGFISPENLGCLEAVVS
LIKLLKTNEWSTVIDKCIHICLIKNGMDHMYHSFDVPKCFMGNPITRDIN
WVMFREFINSLPGTDIPPWNVMTENFKKKCIALINSKFSEFTKLM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7orm Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		R33 V134 F162 K165 H184 Y750 N823 R824 S840 H1185 D1187 V1239 S1240 R1254 F1255 D1262 V1472 K1474 S1497 S1622 Q1693 Y1696
Binding residue
(residue number reindexed from 1)		R33 V134 F162 K165 H184 Y741 N814 R815 S831 H1126 D1128 V1180 S1181 R1195 F1196 D1203 V1413 K1415 S1438 S1550 Q1621 Y1624
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7orm, PDBe:7orm, PDBj:7orm
PDBsum7orm
PubMed35173159
UniProtA5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)

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