Structure of PDB 7ork Chain A Binding Site BS03

Receptor Information

>7ork Chain A (length=2182) Species: 11577 (La Crosse virus)

MDYQEYQQFLARINTARDACVAKDIDVDLLMARKDYFGRELCKSLNIEYR
NDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSNE
SSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELYP
TIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVAHGDFTLTAPWCKTGCPE
FWKHPIYKEFKMSMPVPERRLFEESVKFNAYESERWNTNLVKIREYTKKD
YSEHISKSAKNIFLASGFYKQPNKNEISEGWTLMVERVQDQREISKSLHD
QKPSIHFIWGAHNPGNSNNATFKLILLSKSLQSIKGISTYTEAFKSLGKM
MDIGDKAIEYEEFCMSLKSKALEPKQINNALVLWEQQFMINNDLIDKSEK
LKLFKNFCGIGKHKQFKNKMLEDLEVSKPKILDFDDANMYLASLTMMEQS
KKILSKSNGLKPDNFILNEFGSRIKDANKETYDNMHKIFETGYWQCISDF
STLMKNILSVSQYNRHNTFRIAMCANNNVFAIVFPSADIKTKKATVVYSI
IVLHKEEENIFNPGCLHGTFKCMNGYISISRAIRLDKERCQRIVSSPGLF
LTTCLLFKHDNPTLVMSDIMNFSIYTSLSITKSVLSLTEPARYMIMNSLA
ISSNVKDYIAEKFSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDIYL
SDYDITQKGIKDNRELTSIWFPGSVTLKEYLTQIYLPFYFNAKGLHEKHH
VMVDLAKTILEIECEQRENIKEIWSTNCTKQTVNLKILIHSLCKNLLADT
SRHNHLRNRIENRNNFRRSITTISTFTSSKSCLKIGDFRKEKELRKMRLA
NPMFVTDEQVCLEVGHCNYEMLRNAMPNYTDYISTKVFDRLYELLDKKVL
TDKPVIEQIMDMMIDHKKFYFTFFNKGQKTSKDREIFVGEYEAKMCMYAV
ERIAKERCKLNPDEMISEPGDGKLKVLEQKSEQEIRFLVETTRQKNREID
EAIEALATLGKIEKLSLGKAKGLKMEINADMSKWSAQDVFYKYFWLIALD
PILYPQEKERILYFMCNYMDKELILPDELLFNLLDQKVAYQNDIIATMTN
QLNSNTVLIKRNWLQGNFNYTSSYVHSCAMSVYKEILKEAITLLDGSILV
NSLVHSDDNQTSITIVQDKMENDKIIDFAMKEFERACLTFGCQANMKKTY
VTNCIKEFVSLFNLYGEPFSIYGRFLLTSVGDCAYIGPYEDLASRISSAQ
TAIKHGCPPSLAWVSIAISHWMTSLTYNMLPGQSNDPIDYFPAENRKDIP
IELNGVLDAPLSMISTVGLESGNLYFLIKLLSKYTPVMQKRESVVNQIAE
VKNWKVEDLTDNEIFRLKILRYLVLDAEMDPSDIMGETSDMRGRSILTPR
KFTTAGSLRKLYSFSKYQDRLSSPGGMVELFTYLLEKPELLVTKGEDMKD
YMESVIFRYNSKRFKESLSIQNPAQLFIEQILFSHKPVIDFSGIRDKKEP
DILGKVTFTEAYRLLMRDLSSLELTNDDIQVIYSYIILNDPMMITIANTH
ILSIYGSPQRRMGMSCSTMPEFRNLKLIHHSPALVLRAYSKNNPDIQGAD
PTEMARDLVHLKEFVENTNLEEKMKVRIAMNEAEKGQRDIVFELKEMTRF
YQVCYEYVKSTEHKIKVFILPAKSYTTTDFCSLMQGNLIKDKEWYTVHYL
KQILSGGHKAIMQHNATSEQNIAFECFKLITHFADSFIDSLSRSAFLQLI
IDEFSYKDVKVSKLYDIIKNGYNRTDFIPLLFRTGDLRQADLDKYDAMKS
HERVTWNDWQTSRHLDMGSINLTITGYNRSITIIGEDNKLTYAELCLTRK
TPENITISGRKLLGSRHGLKFENMSKIQTYPGNYYITYRKKDRHQFVYQI
HSHESITRRNEEHMAIIYNEITPVCVVNVAEVDGDQRILIRSLDYLNNDI
FSLSRIKVGLDEFATIKKAHFSKMVSFEGPPIKTGLLDLTELMKSQDLLN
LNYDNIRNSNLISFSKLICCEGSDNINDGLEFLSDDPMNFTEGEAIHSTP
IFNIYYSKRGERHMTYRNAIKLLIERETKIFEEAFTFSENGFISPENLGC
LEAVVSLIKLLKTNEWSTVIDKCIHICLIKNGMDHMYHSFDVPINWVMFR
EFINSLPGTDIPPWNVMTENFKKKCIALINSK

Ligand information

>7ork Chain P (length=1)

a

.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ork Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): Y714 W1847 W1850 Q1851 R1854 H1908 G1909 K2012 A2013 H2014 K2017
• Binding residue (residue number reindexed from 1): Y703 W1806 W1809 Q1810 R1813 H1867 G1868 K1968 A1969 H1970 K1973

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.1.-.-

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0019079 viral genome replication
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:7ork, PDBe:7ork, PDBj:7ork
• PDBsum: 7ork
• PubMed: 35173159
• UniProt: A5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)