Structure of PDB 7orj Chain A Binding Site BS03

Receptor Information

>7orj Chain A (length=2129) Species: 11577 (La Crosse virus)

MDYQEYQQFLARINTARDACVAKDIDVDLLMARKDYFGRELCKSLNIEYR
NDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSNE
SSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELYP
TIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVAHGDFTLTAPWCKTGCPE
FWKHPIYKEFKMSMPVPERRLFEESVKFNAYESERWNTNLVKIREYTKKD
YSEHISKSAKNIFLASGFYKQPNKNEISEGWTLMVERVQDQREISKSLHD
QKPSIHFIWGAHNPGNSNNATFKLILLSKSLQSIKGISTYTEAFKSLGKM
MDIGDKAIEYEEFCMSLKSKALEPKQINNALVLWEQQFMINNDLIDKSEK
LKLFKNFCGIGKHVSKPKILDFDDANMYLASLTMMEQSKKILSKSNGLKP
DNFILNEFGSRIKDANKETYDNMHKIFETGYWQCISDFSTLMKNILSVSQ
YNRHNTFRIAMCANNNVFAIVFPSADIKTKKATVVYSIIVLHKEEENIFN
PGCLHGTFKCMNGYISISRAIRLDKERCQRIVSSPGLFLTTCLLFKHDNP
TLVMSDIMNFSIYTSLSITKSVLSLTEPARYMIMNSLAISSNVKDYIAEK
FSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDIYLSDYDITQKGIKD
NRELTSIWFPGSVTLKEYLTQIYLPFYFNAKGLHEKHHVMVDLAKTILEI
ECEQRENIKEIWSTNCTKQTVNLKILIHSLCKNLLADTSRHNHLRNRIEN
RNNFRRSITTISTFTSSKSCLKIGDFRKEMLRNAMPNYTDYISTKVFDRL
YELLDKKVLTDKPVIEQIMDMMIDHKKFYFTFFNKGQKTSKDREIFVGEY
EAKMCMYAVERIAKERCKLNPDEMISEPGDGKLKVLEQKSEQEIRFLVET
TRQKNREIDEAIEALATLGKIEKLSLGKAKGLKMEINADMSKWSAQDVFY
KYFWLIALDPILYPQEKERILYFMCNYMDKELILPDELLFNLLDQKVAYQ
NDIIATMTNQLNSNTVLIKRNWLQGNFNYTSSYVHSCAMSVYKEILKEAI
TLLDGSILVNSLVHSDDNQTSITIVQDKMENDKIIDFAMKEFERACLTFG
CQANMKKTYVTNCIKEFVSLFNLYGEPFSIYGRFLLTSVGDCAYIGPYED
LASRISSAQTAIKHGCPPSLAWVSIAISHWMTSLTYNMLPGQSNDPIDYF
PAENRKDIPIELNGVLDAPLSMISTVGLESGNLYFLIKLLSKYTPVMQKR
ESVVNQIAEVKNWKVEDLTDNEIFRLKILRYLVLDAEMDPSDIMGETSDM
RGRSILTPRKFTTAGSLRKLYSFSKYQDRLSSPGGMVELFTYLLEKPELL
VTKGEDMKDYMESVIFRYNSKRFKESLSIQNPAQLFIEQILFSHKPVIDF
SGIRDKKEPDILGKVTFTEAYRLLMRDLSSLELTNDDIQVIYSYIILNDP
MMITIANTHILSIYGSPQRRMGMSCSTMPEFRNLKLIHHSPALVLRAYSK
NNPDIQGADPTEMARDLVHLKEFVENTNLEEKMKVRIAMNEAEKGQRDIV
FELKEMTRFYQVCYEYVKSTEHKIKVFILPAKSYTTTDFCSLMQGNLIKD
KEWYTVHYLKQILSSEQNIAFECFKLITHFADSFIDSLSRSAFLQLIIDE
FSYKDVKVSKLYDIIKNGYNRTDFIPLLFRTGDLRQADLDKYDAMKSHER
VTWNDWQTSRHLDMGSINLTITGYNRSITIIGEDNKLTYAELCLTRKTPE
NITISGRKLLGSRHGLKFENMSKIQTYPGNYYITYRKKDRHQFVYQIHSH
ESITRRNEEHMAIIYNEITPVCVVNVAEVDGDQRILIRSLDYLNNDIFSL
SRIKVGLDEFATIKKAHFSKMVSFEGPPIKTGLLDLTELMKSQDLLNLNY
DNIRNSNLISFSKLICCEGSDNINDGLEFLSDDPMNFTEGEAIHSTPIFN
IYYSKRGERHMTYRNAIKLLIERETKIFEEAFTFSENGFISPENLGCLEA
VVSLIKLLKTNEWSTVIDKCIHICLIKNGMDHMYHSFDVPINWVMFREFI
NSLPGTDIPPWNVMTENFKKKCIALINSK

Ligand information

>7orj Chain P (length=1)

a

.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7orj Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): Y714 W1847 W1850 Q1851 R1854 R1907 H1908 K2011 K2012 A2013 H2014 F2015 K2017 L2045
• Binding residue (residue number reindexed from 1): Y691 W1753 W1756 Q1757 R1760 R1813 H1814 K1914 K1915 A1916 H1917 F1918 K1920 L1948

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.1.-.-

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0019079 viral genome replication
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:7orj, PDBe:7orj, PDBj:7orj
• PDBsum: 7orj
• PubMed: 35173159
• UniProt: A5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)