Structure of PDB 7opq Chain A Binding Site BS03

Receptor Information
>7opq Chain A (length=212) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMSFLTEEEQEAIMKVLQRDAALKRAEEDYDYLIKFLALGDSGVGKTSVL
YQYTDGKFNSKFITTVGIDFREKRVVYRASGPDGATGRGQRIHLQLWDTA
GLERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYSENP
DIVLCGNKSDLEDQRVVKEEEAIALAEKYGIPYFETSAANGTNISQAIEM
LLDLIMKRMERC
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7opq Chain A Residue 203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7opq Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Resolution2.23 Å
Binding residue
(original residue number in PDB)		T22 T40
Binding residue
(residue number reindexed from 1)		T47 T65
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0031267 small GTPase binding
Biological Process
GO:0006886 intracellular protein transport

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Molecular Function
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Biological Process
External links
PDB RCSB:7opq, PDBe:7opq, PDBj:7opq
PDBsum7opq
PubMed35308027
UniProtP51159|RB27A_HUMAN Ras-related protein Rab-27A (Gene Name=RAB27A);
Q9HCH5

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