Structure of PDB 7opc Chain A Binding Site BS03

Receptor Information
>7opc Chain A (length=1412) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGCGR
YQPRIRRSGLELYAEWKILLSPERVHEIFKRISDEECFVLGMEPRYARPE
WMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQN
GAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGK
EGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTP
FNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKV
ERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADF
DGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVR
KFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLII
PGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLG
TSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADS
KTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILN
DARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGK
RIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREG
LIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGL
AGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNA
HIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHI
NPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLR
STLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLG
EPATQMTLNAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERA
KDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDV
ARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEK
LVLRIRIMNMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKK
IIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVL
GIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGV
NRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTG
CFDLLLDAEKCK
Ligand information
>7opc Chain T (length=47) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgctctgctccttctcccatcctctcgatggctatgagatcaactag
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7opc Structural basis of human transcription-DNA repair coupling.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		P44 E45 M266 Q267 N272 K331 S332 K346 R358 Q461 T854 A855 Y859 R1416 E1433 E1434 D1437
Binding residue
(residue number reindexed from 1)		P34 E35 M220 Q221 N226 K285 S286 K300 R312 Q415 T808 A809 Y813 R1347 E1364 E1365 D1368
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
2.7.7.6: DNA-directed RNA polymerase.
3.1.13.-
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:1990841 promoter-specific chromatin binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0033120 positive regulation of RNA splicing
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7opc, PDBe:7opc, PDBj:7opc
PDBsum7opc
PubMed34526721
UniProtP11414|RPB1_CRIGR DNA-directed RNA polymerase II subunit RPB1 (Gene Name=POLR2A)

[Back to BioLiP]