Structure of PDB 7o6y Chain A Binding Site BS03

Receptor Information
>7o6y Chain A (length=693) Species: 4952 (Yarrowia lipolytica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEIELTIDGHKVSIEAGSALIQACEKAGVTVPRYCYHDKLAIAGNCRMCL
VDVERAPKPVASCAYPVAPGMVVRTDTERVKQARENVMEMMLQNHPLDCP
VCDQGGECDLQDQSMRYGRDRGRFTEITGKRSTEDKNIGPLVKTSMNRCI
HCTRCVRFANDIAGAPELGSSGRGNDMQIGTYLEKNLNTELSGNVIDLCP
VGALTNKPYAFRARPWELKKTESIDVMDAVGSNIRIDSKGVEVMRVIPRV
HEDVNEEWINDKSRFACDGLKTQRLTTPLIRVGDKFVNATWDDALSTIAK
AYQQKAPKGDEFKAVAGALVEVESMVALKDMTNALGSENTTTDTPNGNSA
PAHGITFRSNYLFNSSIAGIEDADAILLVGTNPRREAAVMNARIRKAWLR
QELEIASVGPTLDATFDVAELGNTHADLEKALSGEFGEVLKNAKNPLIIV
GSGITDREDAGAFFNTIGKFVESTPSVLNENWNGYNVLQRSASRAGAYDI
GFTPSDEASKTTPKMVWLLGADEVAASDIPADAFVVYQGHNGDVGAQFAD
VVLPGAAYTEKAGTYVNTEGRSQISRAATGPPGGAREDWKILRAVSEYLG
VALPYEDAYEVRDRLAEISPSLVRYDLVEPTVFGDVAVQHSLVGPNGSVT
PSSAPLTETIENFYMTDSISRSSPTMAKSSIAFNKDNKKNQAF
Ligand information
Ligand IDFES
InChIInChI=1S/2Fe.2S
InChIKeyNIXDOXVAJZFRNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04[Fe]1S[Fe]S1
CACTVS 3.341
OpenEye OEToolkits 1.5.0		S1[Fe]S[Fe]1
FormulaFe2 S2
NameFE2/S2 (INORGANIC) CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7o6y Chain A Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7o6y High-resolution structure and dynamics of mitochondrial complex I-Insights into the proton pumping mechanism.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C69 Y70 G78 C80 R81 C83 C97
Binding residue
(residue number reindexed from 1)		C35 Y36 G44 C46 R47 C49 C63
Annotation score1
Enzymatic activity
Enzyme Commision number 1.6.99.3: Deleted entry.
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0042773 ATP synthesis coupled electron transport
GO:0045333 cellular respiration
GO:1902600 proton transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0045271 respiratory chain complex I

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7o6y, PDBe:7o6y, PDBj:7o6y
PDBsum7o6y
PubMed34767441
UniProtF2Z6F1

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