Structure of PDB 7o45 Chain A Binding Site BS03
Receptor Information
>7o45 Chain A (length=141) Species:
9606
(Homo sapiens) [
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DQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFL
ELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTA
AEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDT
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
7o45 Chain A Residue 603 [
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Receptor-Ligand Complex Structure
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PDB
7o45
Structure of the DNMT3B ADD domain suggests the absence of a DNMT3A-like autoinhibitory mechanism.
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
C490 C495 C524 C527
Binding residue
(residue number reindexed from 1)
C77 C82 C111 C114
Annotation score
1
Enzymatic activity
Enzyme Commision number
2.1.1.37
: DNA (cytosine-5-)-methyltransferase.
External links
PDB
RCSB:7o45
,
PDBe:7o45
,
PDBj:7o45
PDBsum
7o45
PubMed
35760008
UniProt
Q9UBC3
|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)
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