Structure of PDB 7ne3 Chain A Binding Site BS03

Receptor Information

>7ne3 Chain A (length=416) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SCRCVIIEKDEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVIYT
GKEGKSSQGCPIAKWVVRRSSSEEKLLCLVRERAGHTCEAAVIVILILVW
EGIPLSLADKLYSELTETLRKYGTLTNRRCALNEERTCACQGLDPETCGA
SFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESHLQNLSTLM
APTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHAHR
DLHNMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGSVE
AQEEKKRSGAIQVLSSFRRKVRMLAEPVKTCRGSDEVWSDSEQSFLDPDI
GGVAVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMNE
PKHGLALWEAKMAEKA

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

7ne3 Chain A Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7ne3 Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function.
Resolution	2.26 Å
Binding residue (original residue number in PDB)	C1193 C1271 C1273 H1380
Binding residue (residue number reindexed from 1)	C60 C138 C140 H247
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.11.80: methylcytosine dioxygenase.

Gene Ontology

	Molecular Function
GO:0070579	5-methylcytosine dioxygenase activity

	Biological Process
GO:0141166	chromosomal 5-methylcytosine DNA demethylation pathway

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Molecular Function

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Biological Process

External links

PDB	RCSB:7ne3, PDBe:7ne3, PDBj:7ne3
PDBsum	7ne3
PubMed	36070377
UniProt	Q6N021\|TET2_HUMAN Methylcytosine dioxygenase TET2 (Gene Name=TET2)

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