Structure of PDB 7n0z Chain A Binding Site BS03

Receptor Information
>7n0z Chain A (length=393) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMSDLPLRFPYGRPEFLGLSQDEVEASADHIARPILILKETRRLPWATGY
AEVINAGKSTHNEDQASCEVLTVKVSCHYWSLFDGHAGSGAAVVASRLLQ
HHITEQLQDIVDILKIPHECLVIGALESAFKEMDLQIERERSSYNISGGC
TALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLA
FMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLK
FPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIY
DLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTL
AAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIHGNK
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7n0z Chain A Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7n0z Structural basis for the specificity of PPM1H phosphatase for Rab GTPases.
Resolution2.19 Å
Binding residue
(original residue number in PDB)		D288 D437
Binding residue
(residue number reindexed from 1)		D169 D318
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0004722 protein serine/threonine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7n0z, PDBe:7n0z, PDBj:7n0z
PDBsum7n0z
PubMed34580980
UniProtQ9ULR3|PPM1H_HUMAN Protein phosphatase 1H (Gene Name=PPM1H)

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