Structure of PDB 7lmw Chain A Binding Site BS03

Receptor Information
>7lmw Chain A (length=208) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAMAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGG
GPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQ
IPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEK
GVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPHRALRTA
PIQPRVWE
Ligand information
Ligand IDY6P
InChIInChI=1S/C13H11N3O2/c1-7-3-2-4-9-10(8-5-14-15-6-8)12(13(17)18)16-11(7)9/h2-6,16H,1H3,(H,14,15)(H,17,18)
InChIKeyGUEVKZFKUSZADK-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7Cc1cccc2c1[nH]c(c2c3c[nH]nc3)C(=O)O
CACTVS 3.385Cc1cccc2c1[nH]c(C(O)=O)c2c3c[nH]nc3
FormulaC13 H11 N3 O2
Name7-methyl-3-(1~{H}-pyrazol-4-yl)-1~{H}-indole-2-carboxylic acid
ChEMBL
DrugBank
ZINC
PDB chain7lmw Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lmw A fragment-based approach to discovery of Receptor for Advanced Glycation End products inhibitors.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		D73 R77 P87
Binding residue
(residue number reindexed from 1)		D54 R58 P68
Annotation score1
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:7lmw, PDBe:7lmw, PDBj:7lmw
PDBsum7lmw
PubMed34156100
UniProtQ15109|RAGE_HUMAN Advanced glycosylation end product-specific receptor (Gene Name=AGER)

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