Structure of PDB 7l35 Chain A Binding Site BS03

Receptor Information
>7l35 Chain A (length=634) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMV
ETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVA
QATGRQLESVRAEAAEKGDVGLVAENSPPPPLTASGVFSKFRDIARLTGS
ASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAV
SLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRII
PVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEY
KYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFI
LDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNG
ESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKD
SCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLG
RGKWAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVL
PSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKG
ISLRFPRFIRVREDKQPEQATTSAQVACLYRKQS
Ligand information
Receptor-Ligand Complex Structure
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PDB7l35 LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		R305 T415 G416 S417 A418 T420 R451 G453 A455 Q457 S458 Q636 T639 T640 R641 R643 R738 R768 G776 K795 G797 S850 L851 S852 P853 Y855 S869 L870 F872
Binding residue
(residue number reindexed from 1)		R46 T148 G149 S150 A151 T153 R184 G186 A188 Q190 S191 Q369 T372 T373 R374 R376 R471 R501 G509 K528 G530 S583 L584 S585 P586 Y588 S602 L603 F605
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7l35, PDBe:7l35, PDBj:7l35
PDBsum7l35
PubMed33444456
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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