Structure of PDB 7l34 Chain A Binding Site BS03 |
| >7l34 Chain A (length=637) Species: 9606 (Homo sapiens)
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SNDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMV
ETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVA
QATGRQLESVRAEAAEKGDVGLVAENSRLMLPPPPLTASGVFSKFRDIAR
LTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAAL
SQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDL
DRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAF
TCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSV
TSFILDTEAVAWDREKKQIQPFQVLTTLKRKEVDASEIQVQVCLYAFDLI
YLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQ
SVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIG
AYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLK
ALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVD
SDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQ |
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| PDB | 7l34 LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency. |
| Resolution | 1.901 Å |
Binding residue
(original residue number in PDB) | R305 T415 G416 A418 T420 R451 G453 A455 Q457 S458 R557 Q636 T639 K642 R738 G767 R768 G769 K770 G776 K795 G797 S850 L851 S852 P853 Y855 S869 L870 F872 |
Binding residue
(residue number reindexed from 1) | R46 T152 G153 A155 T157 R188 G190 A192 Q194 S195 R294 Q373 T376 K379 R475 G504 R505 G506 K507 G513 K532 G534 S587 L588 S589 P590 Y592 S606 L607 F609 |
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| Enzyme Commision number |
6.5.1.1: DNA ligase (ATP). |
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