Structure of PDB 7kir Chain A Binding Site BS03

Receptor Information

>7kir Chain A (length=326) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MSDILQELLRVSEKAANIARACRQQETLFQLDFKTLAAVLVQEVIKENME
NKFPGLGKKIFGEESNELTNDLGEKIIMRLGPTEEETVALLSKVLNGNKL
ASEALAKVVHQDVFFSDPALDSVEINIPQDILGIWVDPIDSTYQYIKGSA
DITPNQGIFPSGLQCVTVLIGVYDIQTGVPLMGVINQPFVSQDLHTRRWK
GQCYWGLSYLGTNIHSLLPPVSVVISTSEKETRIFRAAGAGYKSLCVILG
LADIYIFSEDTTFKWDSCAAHAILRAMGGGMVDLKECLERPQLVYHVGNQ
WANKGGLIAYRSEKQLETFLSRLLQH

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

7kir Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7kir A structural basis for lithium and substrate binding of an inositide phosphatase.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	E79 D153 I155
Binding residue (residue number reindexed from 1)	E63 D137 I139
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.1.3.57: inositol-1,4-bisphosphate 1-phosphatase.

Gene Ontology

	Molecular Function
GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding
GO:0052829	inositol-1,3,4-trisphosphate 1-phosphatase activity

	Biological Process
GO:0046854	phosphatidylinositol phosphate biosynthetic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:7kir, PDBe:7kir, PDBj:7kir
PDBsum	7kir
PubMed	33172890
UniProt	P21327\|INPP_BOVIN Inositol polyphosphate 1-phosphatase (Gene Name=INPP1)

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