Structure of PDB 7ka0 Chain A Binding Site BS03

Receptor Information

>7ka0 Chain A (length=339) Species: 83332 (Mycobacterium tuberculosis H37Rv)

MLSPEALTTAVDAAQQAIALADTLDVLARVKTEHLGDRSPLALARQALAV
LPKEQRAEAGKRVNAARNAAQRSYDERLATLRAERDAAVLVAEGIDVTLP
STRVPAGARHPIIMLAEHVADTFIAMGWELAEGPEVETEQFNFDALNFPA
DHPARGEQDTFYIAPEDSRQLLRTHTSPVQIRTLLARELPVYIISIGRTF
RTDELDATHTPIFHQVEGLAVDRGLSMAHLRGTLDAFARAEFGPSARTRI
RPHFFPFTEPSAEVDVWFANKGAAWVEWGGCGMVHPNVLRATGIDPDLYS
GFAFGMGLERTLQFRNGIPDMRDMVEGDVRFSLPFGVGA

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7ka0 Chain A Residue 410

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ka0 Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): E259 H287
• Binding residue (residue number reindexed from 1): E259 H285
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.1.1.20: phenylalanine--tRNA ligase.

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0000166 nucleotide binding
• GO:0000287 magnesium ion binding
• GO:0004812 aminoacyl-tRNA ligase activity
• GO:0004826 phenylalanine-tRNA ligase activity
• GO:0005524 ATP binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation
• GO:0006432 phenylalanyl-tRNA aminoacylation
• GO:0043039 tRNA aminoacylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005886 plasma membrane

External links

• PDB: RCSB:7ka0, PDBe:7ka0, PDBj:7ka0
• PDBsum: 7ka0
• PubMed: 33885823
• UniProt: P9WFU3|SYFA_MYCTU Phenylalanine--tRNA ligase alpha subunit (Gene Name=pheS)