Structure of PDB 7jm6 Chain A Binding Site BS03

Receptor Information
>7jm6 Chain A (length=667) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSLKYESLDYDNSENQLFLEEERRINHAAFRTVEIKRWVICAMIGILTGL
VACFIDIVVENLAGLKYRVVKDNIDKFTEKGGLSFSLLLWATLNASVVMV
GSVIVAFIEPVAAGSGIPQIKCYLNGVKIPHVVRLKTLVIKVCGVILSVV
GGLAVGKEGPMIHSGAVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFV
SAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLN
SVLSVYHGNAWDLSSPGLINFGRFDSEKMGYTIQEIPIFIFMGVVGGILG
ALFNALNYWLTMFRIRYIHRPCLQVIEAMLVAAVTAAVGFVMIYCSRAFF
NTPEKSVVNLFHDPPGSYNPMTLGMFTLMYFFLACWTYGLTVSAGVFIPS
LLIGAAWGRLFGISLSYLSKGSIWADPGKYALMGAAAQLGGIVRMTLSLT
VIMMEATGNVTYGFPIMLVLMTAKIVGDYFVEGLYDMHIQLQSVPFLHWE
APVTSHSLTAREVMSTPVTCLRRIERVGTVVDILSDTSSNHNGFPVVESN
PNTTQVAGLRGLILRSQLIVLLKHKVFVERRLKLKDFRDAYPRFPPIQSI
HVSQDERECMIDLSEFMNPSPYTVPREASLPRVFKLFRALGLRHLVVVNN
HNEVVGMVTRKDLARYR
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain7jm6 Chain A Residue 904 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7jm6 Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1.
Resolution2.92 Å
Binding residue
(original residue number in PDB)		G240 E242 G507 F509 I510
Binding residue
(residue number reindexed from 1)		G156 E158 G395 F397 I398
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005247 voltage-gated chloride channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jm6, PDBe:7jm6, PDBj:7jm6
PDBsum7jm6
PubMed32749217
UniProtQ5ZL60

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