Structure of PDB 7fho Chain A Binding Site BS03

Receptor Information
>7fho Chain A (length=647) Species: 3702,6100 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTPFQKAAALVDLAEDGIGLPVEILDQSSFGESARYYFIFTRLDLIWSLN
YFALLFLNFFEQPLWCEKNPKPSCKDRDYYYLGELPYLTNAESIIYEVIT
LAILLVHTFFPISYEGSRIFWTSRLNLVKVACVVILFVDVLVDFLYLLPF
RIAPYVRVIIFILSIRELRDTLVLLSGMLGTYLNILALWMLFLLFASWIA
FVMFEATQQGLTVFTSYGATLYQMFILFTTSNNPDVWIPAYKSSRWSSVF
FVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVSGMDQMKRRMLEKAFGLI
DSDKNGEIDKNQCIKLFEQLTNYRTLPKISKEEFGLIFDELDDTRDFKIN
KDEFADLCQAIALRFQKPSLFEHFPQIYHSALSQQLRAFVRSPNFGYAIS
FILIINFIAVVVETTLAIEESSAQKPWQVAEFVFGWIYVLEMALKIYTYG
FENYWREGANRFDFLVTWVIVIGETATFITPDENTFFSNGAWIRYLLLAR
MLRLIRLLMNVQRYRAFIATFITLIPSLMPYLGTIFCVLCIYCSIGVQVF
GGLVNAGNKKLFETELAEDDYLLFNFNDYPNGMVTLFNLLVMGNWQVWME
SYKDLTGTWWSITYFVSFYVITILLLLNLVVAFVLEAFFTELDLEEE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7fho Chain A Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7fho Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		E341 T378 D380 K382 N384 E387
Binding residue
(residue number reindexed from 1)		E307 T344 D346 K348 N350 E353
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005216 monoatomic ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0042802 identical protein binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0008218 bioluminescence
GO:0009845 seed germination
GO:0010119 regulation of stomatal movement
GO:0019722 calcium-mediated signaling
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0080141 regulation of jasmonic acid biosynthetic process
Cellular Component
GO:0000325 plant-type vacuole
GO:0005575 cellular_component
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7fho, PDBe:7fho, PDBj:7fho
PDBsum7fho
PubMed34845029
UniProtP42212|GFP_AEQVI Green fluorescent protein (Gene Name=GFP);
Q94KI8|TPC1_ARATH Two pore calcium channel protein 1 (Gene Name=TPC1)

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