Structure of PDB 7e9l Chain A Binding Site BS03

Receptor Information
>7e9l Chain A (length=524) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RIDYPKALQILTEGGTHMVCTGRTHTDRLCRFKWLCYSSEAEEFIFFHGN
ASVMLPSLGSRRFQPALLDLSTVEDHNTQYFNFVELPAAALRFMPKPVFV
PDVALIANRFNPDNLMHVFHDDLLPLFYTLRQFPGLAREARLFFMEGWGE
GAHFDLYKLLSPKQPLLRAQLKALGRLLCFSHAFVGLSKVTTWYQYGFVQ
PQGPKANILVSGNEIRQFAHFLMEKLNVSEEYILVFSRTQNRLILNEAEL
LLALAQEFQMKTVTVSLEDHAFADVVRLVSNASMLVSMHGAQLVTALFLP
RGAAVVELFPYAVNPDHYTPYKTLATLPGMDLQYIAWQNTMPENTVTHPE
RPWDQGGIAHLDRAEQARILQSREVPRHLCCRNPEWLFRIYQDTKVDIPS
LIQTIRRVVKGHPGPRKQKWTVSLYPGKVREARCQASVQGASEARLSVSW
QIPWNLKYLKVREVKYEVWLQEQGENTYVPYMLALQNHTFTENIKPFTTY
LVWIRCIFNKTLLGPFADVLVCST
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain7e9l Chain C Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7e9l The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on alpha-dystroglycan.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		H166 C436
Binding residue
(residue number reindexed from 1)		H117 C380
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.1.312: protein O-mannose beta-1,4-N-acetylglucosaminyltransferase.
Gene Ontology
Molecular Function
GO:0008375 acetylglucosaminyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0097363 protein O-acetylglucosaminyltransferase activity
Biological Process
GO:0001764 neuron migration
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0035269 protein O-linked mannosylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7e9l, PDBe:7e9l, PDBj:7e9l
PDBsum7e9l
PubMed33893702
UniProtQ5NDF2|PMGT2_BOVIN Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (Gene Name=POMGNT2)

[Back to BioLiP]