Structure of PDB 7dia Chain A Binding Site BS03

Receptor Information
>7dia Chain A (length=1072) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EWIHEKSPKHNSYDIIEKRYNEEFKMTYTVYQHKKAKTQVISLGTNDPLD
VEQAFAFYVKTLTHSGKGIPHILEHSVLSGSKNYNYKNSIGLLEKGTLHT
HLNAYTFNDRTVYMAGSMNNKDFFNIMGVYMDSVFQPNVLENKYIFETEG
WTYEVEKLKEDEKGKAEIPQMKDYKVSFNGIVYNEMKGALSSPLEDLYHE
EMKYMFPDNVHSNNSGGDPKEITNLTYEEFKEFYYKNYNPKKVKVFFFSK
NNPTELLNFVDQYLGQLDYSKYRDDAVESVEYQTYKKGPFYIKKKYGDHS
EEKENLVSVAWLLNPKVDLSLENPTDYFVLLIINNLLIHTPESVLYKALT
DCGLGNNVIDRGLNDSLVQYIFSIGLKGIKRNNEKIKNFDKVHYEVEDVI
MNALKKVVKEGFNKSAVEASINNIEFILKEANLKTSKSIDFVFEMTSKLN
YNRDPLLIFEFEKYLNIVKNKIKNEPMYLEKFVEKHFINNAHRSVILLEG
DENYAQEQENLEKQELKKRIENFNEQEKEQVIKNFEELSKYKNAEESPEH
LNKFPIISISDLNKKTLEVPVNVYFTNINENNNIMETYNKLKTNEHMLKD
NMDVFLKKYVLKKYEGNVPILVYEMPTTGIVYLQFVFSLDHLTVDELAYL
NLFKTLILENKTNKRSSEDFVILREKNIGSMSANVALYSKDDHLNVTDKY
NAQALFNLEMHVLSHKCNDALNIALEAVKESDFSNKKKVIDILKRKINGM
KTTFSEKGYAILMKYVKAHLNSKHYAHNIIYGYENYLKLQEQLELAENDF
KTLENILVRIRNKIFNKKNLMVSVTSDYGALKHLFVNSNESLKNLVSYFE
ENDKYIMGWNEEIKSKKLFDEEKVKKEFFVLPTFVNSVSMSGILFKPGEY
LDPSFTVIVAALKNSYLWDTVRGLNGAYGVFADIEYDGSVVFLSARDPNL
EKTLATFRESAKGLRKMADTMTENDLLRYIINTIGTIDKPRRGIELSKLS
FLRLISNESEQDRVEFRKRIMNTKKEDFYKFADLLESKVNEFEKNIVIIT
TKEKANEYIANVDGEFKKVLIE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7dia Chain A Residue 1211 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7dia Protease in complex with inhibitor
Resolution1.55 Å
Binding residue
(original residue number in PDB)		H129 H133 E243
Binding residue
(residue number reindexed from 1)		H71 H75 E185
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0016485 protein processing
GO:0042540 hemoglobin catabolic process
Cellular Component
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0016020 membrane
GO:0020011 apicoplast
GO:0020020 food vacuole
GO:0031982 vesicle

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Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:7dia, PDBe:7dia, PDBj:7dia
PDBsum7dia
PubMed38593807
UniProtQ76NL8|FCLN_PLAF7 Falcilysin (Gene Name=FLN)

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