Structure of PDB 7d99 Chain A Binding Site BS03

Receptor Information
>7d99 Chain A (length=891) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSSLLNKLANYTNLSQGVVEHEEDPRMGTFIGVYLPCLQNILGVILFLRL
TWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISR
SLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAAG
GEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAI
YAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGL
FCNGSQPSAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVE
KKGVPSVPVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRS
GDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQ
GNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPF
LQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLF
VNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSA
MLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWR
PQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHME
AQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTV
LMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERF
GGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQM
KKDLQMFLYHLRISAEVEVVEMQSNVRRMHTAVKLNGVVLNKSQDAQLVL
LNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVI
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain7d99 Chain A Residue 1303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7d99 Structures and an activation mechanism of human potassium-chloride cotransporters.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		G433 F585 Y589
Binding residue
(residue number reindexed from 1)		G342 F494 Y498
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015293 symporter activity
GO:0015377 chloride:monoatomic cation symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0019901 protein kinase binding
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0006884 cell volume homeostasis
GO:0007268 chemical synaptic transmission
GO:0055064 chloride ion homeostasis
GO:0055075 potassium ion homeostasis
GO:0055085 transmembrane transport
GO:0071333 cellular response to glucose stimulus
GO:0071805 potassium ion transmembrane transport
GO:1902476 chloride transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0045202 synapse

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7d99, PDBe:7d99, PDBj:7d99
PDBsum7d99
PubMed33310850
UniProtQ9Y666|S12A7_HUMAN Solute carrier family 12 member 7 (Gene Name=SLC12A7)

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