Structure of PDB 7cy8 Chain A Binding Site BS03

Receptor Information
>7cy8 Chain A (length=858) Species: 3055,83333 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVIWINGDKGYNGLAEVGKKFEKDTVTVEHPDKLEEKFPQVAADIIFWAH
DRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGKLIAYPIAVEALS
LIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAAD
GGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAE
AAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKGQPSKPFVGVLSA
GINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKD
PRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDAALAAA
QTNAARAAAMSVALASEYQLVQNAQLPQRWSQSARKSLAILEATARKEAT
AQMEAAGGSFCGQFPVDPAFKVLSLEYSAPNPDIARAIRRVDSVPNPPLP
SHVVAIQSTAVDADLSLAMGVSLTPGRHTSYLVDARALQQSNSAAVAARK
ADGDKWGPACDEMFRGCRCVTGQEVVFYTAVKEPASLFKPSFDGPAFRPS
WGELSGKATGVVACVLQVPIGKETDIICAEYDNLVSKGQFATVDRFGGDH
TVNMTGNALIQNDGKAISKGYAVAHRARVTSNVYGKANDVSLQRLAETVW
SVVEKRLSFMPAYRDLVITEQGKPFMLGATATNIISLTENQGVMLHLDTD
DGVWTIILWFHRHSGIIAGGEFVLPSLGISFQPLDFTIVVFAANTIVHGT
RPLQTTGKIIRWGSSHFLRFKDVNALAQLGAAYGVDELDAKQRDQLEEVD
AANSKDGVGAARRVASCMAAERKAAIEAQKAACVRGVVMNPCTGRMPSLL
FWQVWRKP
Ligand information
Ligand IDASC
InChIInChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
InChIKeyCIWBSHSKHKDKBQ-JLAZNSOCSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC[CH](O)[CH]1OC(=O)C(=C1O)O
OpenEye OEToolkits 1.5.0C(C(C1C(=C(C(=O)O1)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O
CACTVS 3.341OC[C@H](O)[C@H]1OC(=O)C(=C1O)O
ACDLabs 10.04O=C1OC(C(O)=C1O)C(O)CO
FormulaC6 H8 O6
NameASCORBIC ACID;
Vitamin C
ChEMBLCHEMBL196
DrugBankDB00126
ZINCZINC000100006770
PDB chain7cy8 Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7cy8 Molecular mechanism for vitamin C-derived C 5 -glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		S335 T337 V342 I356 H397 T399
Binding residue
(residue number reindexed from 1)		S686 T688 V693 I707 H748 T750
Annotation score3
Enzymatic activity
Enzyme Commision number 1.14.99.-
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0015144 carbohydrate transmembrane transporter activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0120204 methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity
GO:1901982 maltose binding
Biological Process
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0010109 regulation of photosynthesis
GO:0015768 maltose transport
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042956 maltodextrin transmembrane transport
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cy8, PDBe:7cy8, PDBj:7cy8
PDBsum7cy8
PubMed33531488
UniProtA0A2K3D5Z7;
P0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE)

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