Structure of PDB 7c24 Chain A Binding Site BS03

Receptor Information
>7c24 Chain A (length=372) Species: 479435 (Kribbella flavida DSM 17836) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLDSHELARLHELARHSHAVITRHQDAGGAYPAAPTFSAYRGYAWLRDGS
FTAEGISRYGDVASAGRFHDWVDGVLRRRRGQVDDLLAAVDRGEVPSNEG
MLPTRFTFDGNDGSDPWWDFQTDGYGMWLWSVVTHAARHGLDLERWRAGI
DVAVDYLLAFWDRPCYDWWEEHVEHRHVSTLGAIHGGLVAVGTCAALRSA
PWSAATLQVAARIRSLVSAEGVVDGHLVKWLGSSAVDGSLPACVVPFGLV
PPDDDVAAMTRAAVAKDLDVDGGVHRFAADVYYGGGQWILLSALLGWNLA
AAGDTAGALRHLRWIADQADADGDLPEQVPHHLLHPGSRAEWVARWGTVA
TPLLWSHGMYLILADELGLLPP
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain7c24 Chain A Residue 405 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7c24 Structural insights reveal the second base catalyst of isomaltose glucohydrolase.
Resolution1.71 Å
Binding residue
(original residue number in PDB)		R88 D159 D163 P209 W210
Binding residue
(residue number reindexed from 1)		R80 D151 D155 P201 W202
Annotation score1
Enzymatic activity
Enzyme Commision number 3.2.1.205: isomaltose glucohydrolase.
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0000272 polysaccharide catabolic process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c24, PDBe:7c24, PDBj:7c24
PDBsum7c24
PubMed34665923
UniProtD2PPM8|IMGH_KRIFD Isomaltose glucohydrolase (Gene Name=Kfla_1896)

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