Structure of PDB 7bqu Chain A Binding Site BS03

Receptor Information
>7bqu Chain A (length=109) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASN
LNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGL
TRSALLPTI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7bqu Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7bqu Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide.
Resolution1.9 Å
Binding residue
(original residue number in PDB)
C323 C326 C391 C394
Binding residue
(residue number reindexed from 1)
C6 C9 C74 C77
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:7bqu, PDBe:7bqu, PDBj:7bqu
PDBsum7bqu
PubMed32929090
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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