Structure of PDB 7bkq Chain A Binding Site BS03

Receptor Information

>7bkq Chain A (length=640) Species: 10090 (Mus musculus)

LQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASE
SGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVK
SYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYN
NIMRRYLKQKLRNNDLKKQNKPAIPLPQILGLTASPGVGAAKKQSEAEKH
ILNICANLDAFTIKTVKENLGQLKHQIKKFVIANPFKEKLLEIMASIQTY
CQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQIN
DTIRMIDAYSHLETFYTDEKEKKFAVLNDKLDETDEFLMNLFFDNKKMLK
KLAENPEKLIKLRNTILEQFTRSSSRGIIFTKTRQSTYALSQWIMENAKF
AEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEINLLIATTVAEE
GLDIKECNIVIRYGLSTYVLVTEREIVNDFREKMMYKAINRVQNMKPEEY
AHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSMLVCSGEN
IHVIEKMHHVNMTPEFKGLYIVRENKNGEIICKCGQAWGTMMVHKGLDLP
CLKIRNFVVNFKNNSPKKQYKKWVELPIRFPDLDYSEYCL

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7bkq Chain A Residue 1101

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7bkq MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): C907 C962 C964
• Binding residue (residue number reindexed from 1): C538 C582 C584
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

External links

• PDB: RCSB:7bkq, PDBe:7bkq, PDBj:7bkq
• PDBsum: 7bkq
• PubMed: 34795277
• UniProt: Q8R5F7|IFIH1_MOUSE Interferon-induced helicase C domain-containing protein 1 (Gene Name=Ifih1)