Structure of PDB 7bil Chain A Binding Site BS03

Receptor Information

>7bil Chain A (length=436) Species: 751945 (Thermus oshimai JL-2)

GLSSEQQRAFLAVTQTPHPAHLITGPAGTGKTTLLYALQEFYKGRAVTLA
PTGTAALQARGQTVHSFFRFPARLLRYRHPEDIRPPGPHSPLRKAIEQME
VLILDEVGMVRVDLLEAMDWALRKTRKRLEEPFGGVKVLLLGDTRQLEPV
VPGGEEALYIARTWGGPFFFQAHVWEEVALRVHRLWESQRQREDPLFAEL
LKRLRQGDPQALETLNRAAVRPDGGEEPGTLILTPRRKEADALNLKRLEA
LPGKPLEYQAQVKGEFAETDFPTEAALTLKKGAQVILLRNDPLGEYFNGD
LGWVEDLEAEALAVRLKRNGRRVVIRPFVWEKIVYTYDSEREEIKPQVVG
TFRQVPVRLAWALTVHKAQGLTLDKVHLELGRGLFAHGQLYVALTRVRRL
QDLSLSRPIAPTELLWRPEVEVFETRIQEGIWQKSH

Ligand information

• Ligand ID: ALF
• InChI: InChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
• InChIKey: UYOMQIYKOOHAMK-UHFFFAOYSA-J
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: F[Al-](F)(F)F
• Formula: Al F4
• Name: TETRAFLUOROALUMINATE ION
• DrugBank: DB04444
• PDB chain: 7bil Chain A Residue 1003

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7bil Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.
• Resolution: 2.21 Å
• Binding residue (original residue number in PDB): A93 G94 K97 E172 Q212 R256 G436 R462
• Binding residue (residue number reindexed from 1): A27 G28 K31 E106 Q146 R190 G370 R396
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003678 DNA helicase activity
• GO:0004386 helicase activity
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000723 telomere maintenance
• GO:0006281 DNA repair
• GO:0032508 DNA duplex unwinding

External links

• PDB: RCSB:7bil, PDBe:7bil, PDBj:7bil
• PDBsum: 7bil
• PubMed: 33784404
• UniProt: K7RJ88