Structure of PDB 7bgm Chain A Binding Site BS03

Receptor Information
>7bgm Chain A (length=213) Species: 3880 (Medicago truncatula) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNAVDSLLDSVKWDNKGLAVAIAQNVDTGAILMQGFANREAVATTISSRK
ATFYSRSRSSLWTKGETSNNFINVHDVFLDCDRDSIIYLGKPDGPTCHTG
AETCYYTPVFDLLKEEEVEGNKLALTSLYALESTISQRKAEVVSWTKRLL
LNDKLLCSKIREEANELCETLENNEDKSRTASEMADVLYHAMVLLALKDV
KVEEVLQVLRQRF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7bgm Chain A Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7bgm Structural and mechanistic insights into the bifunctional HISN2 enzyme catalyzing the second and third steps of histidine biosynthesis in plants.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		E214 E234 D237
Binding residue
(residue number reindexed from 1)		E163 E183 D186
Annotation score1
Enzymatic activity
Enzyme Commision number 3.-.-.-
3.5.4.19: phosphoribosyl-AMP cyclohydrolase.
3.6.1.31: phosphoribosyl-ATP diphosphatase.
Gene Ontology
Molecular Function
GO:0004635 phosphoribosyl-AMP cyclohydrolase activity
GO:0004636 phosphoribosyl-ATP diphosphatase activity
Biological Process
GO:0000105 L-histidine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7bgm, PDBe:7bgm, PDBj:7bgm
PDBsum7bgm
PubMed33958623
UniProtA0A072U2X9

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