Structure of PDB 7arz Chain A Binding Site BS03

Receptor Information

>7arz Chain A (length=361) Species: 3218 (Physcomitrium patens)

AFSYSSAAGGESKKILGVFFAAHEYAKNPEFLGCVENALGIREWLESKGH
KYVVTSDKDGPDSELDKELADAHILITTPFHPAYMTKERLAKAKNLELLV
TAGVGSDHIDLHAAAEKGLTVSEVTGSNVTSVAEDEVLRILVLVRNFAPG
WKQVSEGGWNVAAVVHHAYDLIDRTVGTVGGGRIGQELMKRLKGFGLKEM
LYYDRNSLGAEREKELGCKRETDLDTMLSKCDVVVVNTPLTDQTRGLFNK
ERIAKMKKGAYLVNNARGAIADTEAVKEACESGHLGGYGGDVWNAQPAGK
DHPWRYMPNHAMTPHISGTTLDAQKRFAAGTKDMIDRWLKHEAFPEQNYI
VREGKLASQYL

Ligand information

• Ligand ID: AZI
• InChI: InChI=1S/N3/c1-3-2/q-1
• InChIKey: IVRMZWNICZWHMI-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [N-]=[N+]=[N-]
• Formula: N3
• Name: AZIDE ION
• ChEMBL: CHEMBL79455
• PDB chain: 7arz Chain A Residue 503

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7arz Ternary complex of NAD-dependent formate dehydrogenase from Physcomitrium patens
• Resolution: 2.15 Å
• Binding residue (original residue number in PDB): T118 L140 V141 T142
• Binding residue (residue number reindexed from 1): T77 L99 V100 T101
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.17.1.9: formate dehydrogenase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0008863 formate dehydrogenase (NAD+) activity
• GO:0016491 oxidoreductase activity
• GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• GO:0051287 NAD binding

Biological Process

• GO:0042183 formate catabolic process

Cellular Component

• GO:0005739 mitochondrion

External links

• PDB: RCSB:7arz, PDBe:7arz, PDBj:7arz
• PDBsum: 7arz
• UniProt: A9SQZ2