Structure of PDB 7aoe Chain A Binding Site BS03

Receptor Information
>7aoe Chain A (length=1401) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNIAQPVSSEIKSVKFGIYDVDDVEKISVKQIVNPVLLDNLNHPTNGGLY
DLALGPYLKNSVCATCHLDERYCPGHFGHIVLPIPAYHPLFFSQMYNLLR
STCLYCHHFKLSKVKVHLFFCRLKLLDYGLLNESEMVENVSLAKDAATLM
RIRDEFVAKSIADSRQLTTLLLHERKKVVRAFYHAISSRKQCDNCQSFSP
NFRKEGFAKIFEIPLSGKNLQFKYMTSTEVRNHLRRLFVKENVVLSRLYP
ASADMFFLQNIAVPPTRFRPASKMGDEVHENIQNELLTRILQSSIQIASL
SKDSTVEERRSRAFELLINAFVQLQHDVNSLIDSNRNPPPGIKQILEKKE
GLFRKHMMGKRVNYAARSVISPDPNIETNEIGVPPVFATKLTYPEPVTLY
NFNEMRNAVINGPHKWPGASHIQNEDGTLISLMPLTIEQRTALANQLLTP
QSNLISSPYSYSRLINTNKKVYRHVRNGDMLILNRQPTLHKPSMMAHKAR
ILPGEKTIRMHYANCNSYNADFDGDEMNMHFPQSTNARSEAQFIANTDSQ
YLVPTSGDPLRGLIQDHVVMGVWLTCKDTFYTRDEYQQLLFQALKPDETG
MYGRIKTLPPAIQRPGIYWTGKQIISSVLLNLKPSDRPGLNLKSKAKVPG
KYWSPDSEEGSVLFDDGELLCGILDKSSFGASAFGLVHSVHELYGPDIAG
RLLSVLSRLFTAYAQMRGFTCRMDDLRLDEQGDNWRRQLLENGKSFGLEA
ASEYVGLSTDSPIALLNANLEEVYRDDEKLQGLDAAMKGKMNGLTSSIIN
KCIPDGLLTKFPYNHMQTMTVSGAKGSNVNVSQISCLLGQQELEGRRVPL
MVSGKSLPSFVPYETSAKSGGFIASRFLTGIAPQEYYFHCMAGREGLIDT
AVKTSRSGYLQRCLMKHLEGLCVQYDHTVRDSDGSIVQFHYGEDSLDVTK
QKHLTQFEFSAKNYKSLIQKYKVKSVLSAVDSETASSYAKKALKKPYKYD
PVLDKYPPSRYLGSVSEKFQRAVDEYTQKNPDKLIAESKLDDSLLNESKF
KALMQLRYQQSLVDPGESVGVLASQSIGEPSTQMTLNTNVTLGIPRLREI
IMTASANIQTPTMTLRLNDGVSDKRASAFCKEVNKLVLSEVVRQVRVTEK
TYAIRLDLYSRDEYQDEYGVLQEEIESTFSNRFLKILNRIIKSYLAKSKQ
NCKHLDFDYVNGEWATVELVFPINTEKLLMVSLVEKACSETVIHEIPGIT
RCFSKPDTVPKVITEGVNLKAIWEFYNEISMNDIYTNDIAAILRIYGVEA
ARNAIVHEVSSVFGVYGIAVDPRHLSLIADYMTFEGGYKAFNRMGIEYNT
SPFAKMSFETTCHFLTEAALRGDVDDLSNPSSRLVVGRVGNFGTGSFDIF
T
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7aoe Chain A Residue 1702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7aoe Conserved strategies of RNA polymerase I hibernation and activation.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		C106 C228 C231
Binding residue
(residue number reindexed from 1)		C106 C192 C195
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006362 transcription elongation by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7aoe, PDBe:7aoe, PDBj:7aoe
PDBsum7aoe
PubMed33536435
UniProtP15398|RPA1_SCHPO DNA-directed RNA polymerase I subunit rpa1 (Gene Name=rpa1)

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